Altrenogest - Equine (Regumate)

Common Drug Name: Altrenogest

Common Brand Names: Regumate No generic products are available.

Storage: Store at room temperature. Once opened, use the 150 ml bottle within 14 days, and the 250, 300 and 1000 ml bottles by 28 days.

Uses: Regumate is synthetic progesterone hormone that is given orally to prevent estrus in mares or to control the time that estrus starts.

Dose and Administration: Always follow the dosage instructions provided by your veterinarian and the administration directions from the manufacturer. If you have difficulty giving the medication, contact your veterinarian. The medication is to be given orally directly into the mouth using a syringe, or in the mare’s feed. If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once. This medication should only be given to the horse for whom it was prescribed.

Possible Side Effects: Rarely see side effects at labeled dosages. Slight changes in blood levels of calcium, potassium, or liver enzymes may be seen. Consult your veterinarian if you notice any possible side effects. If your horse experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Precautions Precautions in Horses: Not for use in horses hypersensitive (allergic) to altrenogest. Do not use in mares with a previous or current uterine infection or endometritis, or in male horses. Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with altrenogest. Dispose of any unused product, empty containers or partially consumed feed according to local and national requirements.

Human Precautions: Skin contact must be avoided. Use impervious protective gloves when handling altrenogest. The following people should not handle altrenogest: • Women who are or may be pregnant • Persons with known or suspected breast cancer or a history of breast cancer • Persons with known or suspected estrogen-dependent cancer (some uterine cancers) • Persons with cerebrovascular disease (stroke) or coronary artery disease (hardening of the arteries) • Persons with thrombophlebitis or thromboembolic disorders (blood clots) or a history of these diseases • Women with undiagnosed vaginal bleeding • Persons with tumors that developed while they were using oral contraceptives or other estrogen containing products • Persons with liver disease Women of childbearing age should handle this product with extreme caution.

Human Exposure: Altrenogest can be absorbed through the skin. Wear nonporous gloves and personal protective clothing when handling, measuring and administering altrenogest. The absorption of altrenogest can be increased if the medication is trapped between occlusive materials (e.g., latex gloves) and the skin. Avoid contamination of other objects (e.g., pens, countertops, etc.) with altrenogest. If contaminated, wash well with soap and water. If skin is exposed, wash with soap and water. Altrenogest is oily and requires considerable washing and rinsing to remove the drug. Wash hands after use. If eyes are exposed, flush with water for 15 minutes and get medical attention. If swallowed, do not induce vomiting, but contact a physician or poison control center.

Drug, Food, and Test Interactions: Notify your veterinarian of any other medications, including vitamins and supplements, your horse is taking while receiving altrenogest. Consult your veterinarian before using altrenogest with rifampin, since interactions may occur.

Withdrawal Times: Consult your veterinarian and event officials before using altrenogest or any other medication in a performance horse. Not for use in horses intended for food. Signs of Toxicity/Overdose No information is available from the manufacturer. Keep this and all other medications out of the reach of children and animals.

** This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.  Always consult your own veterinarian for specific advice concerning the treatment of your pet.

If you have questions about this medication, please call our Pharmacy at (877) 815-6337 for a consultation