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Selegiline
(Deprenyl,
Anipryl)
Generic
Name:
Selegiline (deprenyl) Generic products are available.
Common
Brand Names:
Anipryl
Eldepryl (human form)
Storage:
Store at
room temperature in a tight, light resistant, childproof container.
Uses:
Selegiline is used to treat cognitive dysfunction and senility in older animals.
Approximately 70% of dogs with cognitive dysfunction will respond to this
medication after one month of treatment. Selegiline is used to treat Cushing's
disease (hyperadrenocorticism) caused by a pituitary tumor in dogs. It is used
to treat Parkinson's disease in humans.
Dose and
Administration:
Always
follow the dosage instructions provided by your veterinarian. If you miss a
dose, give it as soon as you remember. If it is 16 hours or less before the next
scheduled dose, skip the one you missed and go back to the regular schedule. Do
not give 2 doses at once. Give selegiline in the morning for dogs, and in the
evening if used in cats. If you have difficulty giving the medication, contact
your veterinarian. Cushing's disease: If no improvement is seen within 1 month,
the animal should be reevaluated. This medication should only be given to the
pet for whom it was prescribed.
Possible
Side Effects:
May see
loss of appetite, drooling, vomiting, diarrhea, lethargy, anemia (pale gums),
disorientation, restlessness, repetitive behaviors, loss of hearing, itching,
and shaking. Contact your veterinarian if your pet experiences any of these
signs. If your pet experiences an allergic reaction to the medication, signs may
include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting,
shock, seizures, pale gums, cold limbs, or coma. If you observe any of these
signs, contact your veterinarian immediately.
Precautions:
Not for
use in animals who are hypersensitive (allergic) to it. Your veterinarian will
need to perform laboratory tests to determine which type of Cushing's disease
your dog has. Selegiline is not for use in dogs who have Cushing's disease
caused by adrenal gland tumors or from administration of corticosteroids. Do not
use in breeding, pregnant, or lactating animals (female dogs nursing puppies);
the safety of the drug has not been determined in these animals. Do not use this
medication for the treatment of aggression.
Drug and
Food Interactions:
Notify
your veterinarian of any other medications, including vitamins and supplements,
your pet is taking while your pet is receiving selegiline. Do not use within 5
weeks of antidepressants such as amitriptyline, or selective serotonin reuptake
inhibitors (SSRIs) such as Prozac. Do not use with meperidine or other
narcotics. Do not use with phenylpropanolamine (Proin, Propalin, Cystolamine).
Do not use with ephedrine or within 2- 5 weeks of using other monoamine oxidase
inhibitors (MAOIs) such as amitraz (an ingredient in some tick collars, and in
Mitaban, a treatment for mange). Consult your veterinarian before using other
medications or tick collars along with selegiline. Do not give your pet aged
cheese. In combination with selegiline it can cause severe high blood pressure
or death.
Signs of
Toxicity/Overdose:
May see
drooling, slow pupillary response (pupils do not get smaller in bright light),
panting, dehydration, or change in behavior. Signs of overdose may not appear
for 12-24 hours. An overdose is very serious; death may occur. Contact your
veterinarian immediately if you see any of these signs.
Keep this
and all other medications out of the reach of children and pets.
** This information may not cover all possible uses,
directions, side effects, precautions, allergic reactions, drug interactions, or
withdrawal times. Always consult your own veterinarian for specific advice
concerning the treatment of your pet.
If you have questions about this
medication, please call our Pharmacy at (877) 815-6337 for a consultation
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