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Trilostane
(Vetoryl)
Common
Drug Name:
Trilostane
Common
Brand Names:
Vetoryl
Generic products are not available.
Storage:
Store at
room temperature in a tight, light resistant, childproof container.
Uses:
Trilostane is used for the treatment of hyperadrenocorticism, also known as
Cushing’s Disease, in dogs. Trilostane is a treatment for this disease – it is
not a cure.
Dose and
Administration:
Always
follow the dosage instructions provided by your veterinarian. If you have
difficulty giving the medication, contact your veterinarian. Give with food
unless otherwise directed by your veterinarian. If you miss a dose, give it as
soon as you remember. If it is almost time for the next dose, skip the one you
missed and go back to the regular schedule. Do not give 2 doses at once. This
medication should only be given to the pet for whom it was prescribed.
Possible
Side Effects:
Potential
side effects include an unexpected decrease in appetite, vomiting, diarrhea, and
lethargy. Rarely, may see more serious adverse effects including severe
depression, bloody diarrhea, collapse, or other severe reactions, possibly
leading to death. If you think your dog is having a reaction to trilostane,
discontinue use and consult your veterinarian immediately. The signs of
hyperadrenocorticism include increased appetite, increased drinking and
increased urination. As trilostane controls the effects of hyperadrenocorticism,
the signs of this disease should decrease. If your pet experiences an allergic
reaction to the medication, signs may include facial swelling, hives,
scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold
limbs, or coma. If you observe any of these signs, contact your veterinarian
immediately.
Precautions:
Not for
use in animals hypersensitive (allergic) to trilostane. Do not use in pregnant
animals. The safe use of this drug has not been determined in lactating dogs
(females nursing their young) or dogs intended for breeding. Do not use in
animals with primary liver disease or certain kidney diseases. The use of
trilostane may result in the development of hypoadrenocorticism (Addison’s
Disease) and/or corticosteroid withdrawal syndrome. Consult with your
veterinarian regarding the physical examinations and laboratory testing
necessary prior to and during treatment with trilostane.
Human
Precautions:
Wear
gloves and/or wash hands after use. Do not open, empty or divide capsules. Do
not handle capsules if you are pregnant, or may become pregnant. In cases of
human accidental ingestion, seek medical advice immediately and take the labeled
container with you.
Drug,
Food and Test Interactions:
Notify
your veterinarian of any other medications, including vitamins and supplements
your pet is taking while your pet is receiving trilostane. Consult your
veterinarian before using trilostane with ACE inhibitors such as enalapril;
potassium sparing diuretics such as spironolactone; ketoconazole; or potassium
supplements since interactions may occur. Wait at least one month from
discontinuing mitotane treatment before starting treatment with trilostane.
Signs of
Toxicity/Overdose:
May see
lethargy, weakness, vomiting, or collapse. If you know or suspect your pet has
had an overdose, or if you observe any of these signs in your pet, contact your
veterinarian immediately.
Keep this
and all other medications out of the reach of children and pets.
** This information may not cover all possible uses,
directions, side effects, precautions, allergic reactions, drug interactions, or
withdrawal times. Always consult your own veterinarian for specific advice
concerning the treatment of your pet.
If you have questions about this
medication, please call our Pharmacy at (877) 815-6337 for a consultation
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